Map2k1 ELISA Kit for Mouse(Mus musculus) | EIAab.comMap2k1 ELISA Kit for Mouse(Mus musculus)

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Map2k1 (Gene name),

Dual specificity mitogen-activated protein kinase kinase 1 (Protein name ), MP2K1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Map2k1(Mek1;Prkmk1);

Protein name:

Dual specificity mitogen-activated protein kinase kinase 1(MAP kinase kinase 1;MAPKK 1);

Alternative:

MAPK/ERK kinase 1(MEK 1);ERK activator kinase 1;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with MORG1. Interacts with ARRB2. Found in a complex with at least BRAF, HRAS1, MAP2K1, MAPK3 and RGS14 (By similarity). Interacts with VRK2.

Function:

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

393

Sequence:

50:

100:

150:

200:

250:

300:

350:

393:

DLKQLMVHAF | IKRSDAEEVD | FAGWLCSTIG | LNQPSTPTHA | ASI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

10090.ENSMUSP00000005066

SMR:

P31938

String:

P31938

KEGG:

mmu:26395

Pfam:

PF00069

UniGene:

Mm.248907

Uniprot:

P31938

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ELISA Kit for Mouse MAP kinase kinase 1

Cat.:

E10995h

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96T

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ELISA Kit for Mouse MAP kinase kinase 1

Cat.:

E10995m

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Packing:

96T

ELISA Kit for Mouse MAP kinase kinase 1

Cat.:

E10995r

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96T

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ELISA Kit for Mouse MAP kinase kinase 1

MSDS:

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CLIA Kit for Mouse MAP kinase kinase 1

Cat.:

U10995m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse MAP kinase kinase 1

Cat.:

U10995h

Price:

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Manual:

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MSDS:

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Packing:

96T

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CLIA Kit for Mouse MAP kinase kinase 1

MSDS:

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CLIA Kit for Mouse MAP kinase kinase 1

Cat.:

U10995r

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Packing:

96T

Polyclonal Antibody for Mouse MAP kinase kinase 1

Cat.:

P10995Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse MAP kinase kinase 1

Monoclonal Antibody for Mouse MAP kinase kinase 1

Protein for Mouse MAP kinase kinase 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product."
Crews C.M. , Alessandrini A. , Erikson R.L.
Science258:478-480(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6.
tissue: Brain.
3.

"Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product."
Crews C.M. , Erikson R.L.
Proc. Natl. Acad. Sci. U.S.A.89:8205-8209(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 4-20; 71-84; 114-136; 206-234 AND 363-384
tissue: T-cell.
4.

Lubec G. , Klug S.
Submitted (2007-03) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 206-227; 270-291 AND 325-340;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Hippocampus.
5.

"A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf."
Lange-Carter C.A. , Pleiman C.M. , Gardner A.M. , Blumer K.J. , Johnson G.L.
Science260:315-319(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AND ENZYME REGULATION
6.

"Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor."
Duesbery N.S. , Webb C.P. , Leppla S.H. , Gordon V.M. , Klimpel K.R. , Copeland T.D. , Ahn N.G. , Oskarsson M.K. , Fukasawa K. , Paull K.D. , Vande Woude G.F.
Science280:734-737(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE BY ANTHRAX LETHAL FACTOR
7.

"Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists."
Vomastek T. , Schaeffer H.-J. , Tarcsafalvi A. , Smolkin M.E. , Bissonette E.A. , Weber M.J.
Proc. Natl. Acad. Sci. U.S.A.101:6981-6986(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MORG1
8.

"A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal."
Catalanotti F. , Reyes G. , Jesenberger V. , Galabova-Kovacs G. , de Matos Simoes R. , Carugo O. , Baccarini M.
Nat. Struct. Mol. Biol.16:294-303(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION;INTERACTION WITH MAP2K2/MEK2;PHOSPHORYLATION AT THR-292;MUTAGENESIS OF ASN-78 AND THR-292
9.

"Signaling by dual specificity kinases."
Dhanasekaran N. , Premkumar Reddy E.
Oncogene17:1447-1455(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
10.

"The RAF proteins take centre stage."
Wellbrock C. , Karasarides M. , Marais R.
Nat. Rev. Mol. Cell Biol.5:875-885(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ENZYME REGULATION
11.

"The ERK signaling cascade--views from different subcellular compartments."
Yao Z. , Seger R.
BioFactors35:407-416(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
12.

"The ERK cascade: distinct functions within various subcellular organelles."
Wortzel I. , Seger R.
Genes Cancer2:195-209(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION

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